Allergic diseases - highlights in the clinic, mechanisms and by Celso Pereira

By Celso Pereira

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J. Pharmacol. 142: 374-380, ISSN 0007-1188. , & Leurs R. (2005). The histamine H4 receptor as a new therapeutic target for inflammation. Trends Pharmacol. Sci. 26: 462-469, ISSN 0165-6147. , & Thurmond RL. (2007). Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus. J. Allergy Clin. Immunol. 119: 176-183, ISSN 0091-6749. , Francisco A. , & Viana Queiroz M. (2005). Inflammatory cell infiltrate and RANKL/OPG expression in rheumatoid synovium: comparison with other inflammatory arthropathies and correlation with outcome.

Histamine levels in human synovial fluid. J. Rheumatol. 13: 13-14, ISSN 0315-162X. , & Maslinski S. (2007). Distribution pattern of histamine H4 receptor in human synovial tissue from patients with rheumatoid arthritis. Inflamm. Res. 56(Suppl 1): S59-S60, ISSN 10233830. , & Werfel T. (2009). The histamine H4 receptor is functionally expressed on T(H)2 cells. J. Allergy Clin. Immunol. 123: 619-625, ISSN 0091-6749. , & Ueno K. (2005). Histamine H4 receptor expression in human synovial cells obtained from patients suffering from rheumatoid arthritis.

Immediately after the injection of pruritogen, scratching events were counted for 30 min using MicroAct. Fexofenadine (a) or JNJ7777120 (b) was administered orally 20 min before the injection of pruritogen. Values represent the mean ± SEM of four mice. 05 vs. control (Dunnett’s multiple comparisons). Figure reprinted with permission from the Japanese Society of Toxicology. Further, we created a chronic itch model in which repeated application of 2,4,6trinitrochlorobenzene to the back skin of HR-1 mice was seen to elicit frequent scratching behavior at 24 h after challenge.

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