Allogeneic Immunotherapy for Malignant Diseases (Basic and by John Barrett, Yin-Zhen Jiang

By John Barrett, Yin-Zhen Jiang

This crucial reference bargains a accomplished evaluation of the graft-versus-leukemia (GVL) or -tumor (GVT) impression following allogeneic stem mobilephone transplantation and lymphocyte transfusion, overlaying a variety of issues from alloimmune responses to medical functions of GVL, and supplying the fundamentals to appreciate the mechanisms of the GVL impact whereas demonstrating equipment that use the GVL influence to healing a better variety of melanoma sufferers. offers initial facts aiding the concept allogeneic phone treatment can be utilized not just for the remedy of leukemia but additionally for metastatic stable tumors! Written via over forty global well known specialists within the box and containing greater than 1450 references for in-depth exploration of the topic, Allogeneic Immunotherapy for Malignant ailments ·investigates the skill of the donor-and the host-to ruin residual leukemia cells via allogeneic immune response ·determines tips on how to direct immune reactions opposed to hematopoietic malignancies adequately ·reveals which different malignant stipulations might be attentive to allogeneic-mediated graft-versus-tumor reactions ·covers the mechanisms that give a contribution to the improvement of responses to minor histocompatibility complicated (mHC) molecules ·focuses at the biology of effector cells and their function in mediating GVL reactions in continual myeloid leukemia (CML) ·summarizes the putative effect of human mHag at the GVL impression in bone marrow transplantation (BMT) ·addresses the capability and boundaries of oncogene-based immunotherapy ·examines how one can isolate and keep an eye on the GVL component to allograft immunity ·discusses efforts to increase particular anti-leukemic T-cell immunotherapy ·and extra! Attributing the healing impact of allogeneic stem phone transplantation to the GVL or GVT impact, Allogeneic Immunotherapy for Malignant illnesses is an vital reference for hematologists, scientific oncologists, immunologists and researchers within the fields of tumor immunology and melanoma immunotherapy, internists, citizens, and scientific tuition scholars in those disciplines.

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Extra info for Allogeneic Immunotherapy for Malignant Diseases (Basic and Clinical Oncology)

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Long-term acceptance of skin and cardiacallografts after blocking CD40 and CD28 pathways. Nature 1996; 38 1 :434-438. The hypothesis that bone marrow transplantation (BMT) can provide an effective antileukemia reaction was testedin experimental models during thevery earliest days of BMT research. Barnes and coworkers in their 1956 paper entitled “Treatment of Murine Leukaemia withX Rays and Homologous Bone Marrow,” described the potential and problemsof using allogeneic BMT for the treatment of leukemia in this way: When mice are given an otherwise lethal dose of rays to the whole body they can recover if injected intravenously with homologous [allogeneic] myeloid cells.

Lafferty KJ, Bootes A, Dart G, Talrnage DW. Effect of organ culture on the survival of thyroid allografts in mice. Transplantation 1976; 22: 138- 149. 4 l. Auchincloss H Jr, Sultan H. Antigen processing and presentation in tr~nsplantation. Curr Opin Ilnmunol 1996; 8:681-687. 42. , Lee R, Shea S, Markowitz JS, Grusby MJ, Glimcher LH. The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class 11-deficient mice. Proc Natl Acad Sci USA 1993; 90: 3373-3377.

E ~ s i ~ discussed below. The second hypothesis is that the TCRs of allospecific T cells are specific for complexesof allogeneic MHC molecules and individual naturally processed peptides. Owingto polymorphism in the peptide-binding groove, allogeneic MHC molecules are usually occupied by a different repertoire of peptides to which the recipient T cells not havebeen previously exposed. Thus, a single MHC incompatjbility can stimulate a very large number of alloreactive T-cell clones. zllti~~le birznry conzplex model MHC molecules display marked polymorphism, it is possiblethat alloreactive T cells recognizepoly~orphicresidues directly on the allogeneic MHC molecule.

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