By Charles H. Nightingale, Takeo Murakawa, Paul G. Ambrose (Editors)
This up to the moment reference explores the pharmacodynamics of antimicrobials in addition to the absorption, distribution, metabolism, and removal of the foremost sessions of antimicrobials-covering new brokers equivalent to ketolide antibiotics and highlighting the pharmacodynamic courting among drug focus and antimicrobial job, in addition to the connection of pharmacodynamics to bacterial resistance. comprises particular examples and sensible functions for the layout of powerful dosing regimens! Written by way of well-known specialists within the box, Antimicrobial Pharmacodynamics in conception and medical perform describes ·the pharmacodynamic homes of all significant periods of antibiotics ·parameters for microbiological task of antimicrobial brokers equivalent to minimum inhibitory focus (MIC) and minimum bactericidal focus (MBC) ·serum/tissue protein binding and penetration premiums ·differences among in vivo and in vitro postantibiotic results (PAE) ·and extra! With approximately one thousand references, tables, drawings, and illustrations, Antimicrobial Pharmacodynamics in idea and scientific perform is a cutting-edge reference for infectious illness experts, pulmonologists, pharmacists, pharmacologists, microbiologists, organic chemists, epidemiologists, internists, and scholars in those disciplines.
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Extra resources for Antimicrobial Pharmacodynamics in Theory and Clinical Practice, 1st Edition (Infectious Disease and Therapy)
The binding site can be a penicillinbinding protein, a DNA gyrase, a topoisomerase, or a ribosome or any other point of attachment that interferes with the biochemical reactions in the microorganism. The actual site varies depending upon the chemical structure of the class of the agent and also varies somewhat within the same agent class. This ability to bind to an active site can be thought of as being roughly descriptive (although not completely) of what we would commonly call the microbiological activity of the antimicrobial agents.
If the numerator is not accurate and the denominator is not accurate, then the entire ratio cannot be accurate. Reported AUC/MIC ratios are too variable to be considered absolute numbers and should be used only as guides to therapy. As a guide the MIC is very useful, but to consider it to be an absolute, infallible number is misleading and confusing. REFERENCES 1. HP Kuemmerle, T Murakawa, CH Nightingale, eds. Pharmacokinetics of Antimicrobial Agents: Principles, Methods, Applications. Ecomed, 1993.
In this chapter we will use the term MIC; however, the MBC or any other measure of microbiological activity could also be used. It is interesting that the mathematical product of drug concentration in the serum (C p ) multiplied by time is termed the drug’s area under the serum concentration–time curve (AUC). A schematic representation of the AUC in- 30 Nightingale and Murakawa dexed to the MIC of bacteria is shown in Fig. 2. This pharmacodynamic parameter AUC/MIC is an important and fundamental parameter that relates microbiological activity to serum concentration.