Atlas of Bone Pathology by Shi Wei

By Shi Wei

Bone is a residing tissue at risk of increase a various array of inflammatory, metabolic, genetic, reactive, circulatory and neoplastic abnormalities. The Atlas of Bone Pathology describes and selectively illustrates the conventional and pathologic stipulations that afflict human bone, focusing seriously on tumor and tumor-like stipulations of bone and their non-neoplastic mimics. Supplemented with radiographic and precise examine photos, this impressive selection of prime quality electronic photographs reduction carrying on with efforts to acknowledge, comprehend, and adequately interpret the sunshine microscopic findings in bone specimens.

Authored by means of nationally and across the world famous pathologists, The Atlas of Bone Pathology is a concise and resource for either beginner and pro pathologists alike.

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In some lesions, the osteoblasts and stromal cells may have a variable degree of cytologic atypia, thus simulating osteosarcoma. Thus, attention should be paid to the histologic features at low-power magnification and the radiologic appearnce of the lesion to avoid an incorrect diagnosis of malignancy. The cellularity may be variable but typically the osteoblasts do not entirely fill the intertrabecular spaces 31 32 Fig. 18 Osteoblastoma. A closer view demonstrates uneven mineralization of the trabeculae and the abundantly present osteoclast-type multinucleated giant cells.

Osteoid osteoma frequently originates in the cortex. By definition, the tumor is less than 2 cm. The patient typically presents with localized pain of increasing severity that worsens at night and is relieved with aspirin Fig. 6 Osteoid osteoma. Axial CT images of the lesion seen in Fig. 5. Note the central ossification within the nidus (top). Given its characteristic clinical and radiologic features, the primary therapeutic modality is radiofrequency ablation or cryotherapy of the nidus via a percutaneous approach (bottom), a procedure frequently performed prior to pathologic confirmation of the diagnosis.

Fine-needle aspiration of an osteoblastic osteosarcoma. Note the pleomorphic tumor cells. , Warrington, PA) showing metachromatic osteoid is diagnostic but may not always be apparent Fig. 48 Conventional osteosarcoma. Histomorphology of an osteosarcoma with prominent plasmacytoid morphology. The neoplastic cells in benign or malignant boneforming tumors may express CD138 in a membranous fashion. In the setting of minimal tumor osteoid, this may lead to a mistaken diagnosis of plasmacytoma or multiple myeloma 49 50 Fig.

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