By Prof. Dr. med. Fritz Reinhard Matthias (auth.)
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Extra resources for Blood Coagulation Disorders: Hemorrhagic Diatheses and Thromboembolic Diseases
Immune precipitation. To avoid interference with fibrinogen, the test must be carried out in the serum. There are possibilities of error in that some of the split products, particularly the macromolecular ones, are incorporated into the clot during production of the serum, and minimal amounts of fibrinogen or fibrin persist as complexes with split products dissolved in the serum. Preference should be given to the latex agglutination test and the staphylococcal clumping test in the routine laboratory because they are simple to carry out.
Identification of changes in the coagulation system favoring thrombosis, and 3. Therapeutic monitoring of: a) substitution treatment in hemorrhagic diatheses b) fibrinolysis and anticoagulant treatment in thromboembolic diseases. Depending on the situation, the primary diagnosis involves the family and personal history in respect of previous bleeding, the identification of states resulting from previous bleeding or thromboses (joint 37 Table 1. Clinical symptoms of thrombocytic-vascular and plasmatic hemorrhagic diatheses Type of bleeding Thrombocytic-vascular bleeding condition Coagulopathies Frequency and severity of the hemorrhages Bleeding after superficial injury Contusions and hematomas Skin and mucosal bleeding Hemarthrosis Often profuse and prolonged Small and superficial, frequently multiple Very frequent In general, not particularly pronounced Often extensive and deep, usually localized Rare Very rare Bleeding in deep tissue injuries, tooth extractions, etc.
Sem Thrombos Hemostas 3: 1 Kopec M, Latallo ZS (1978) Fibrinogen and fibrin degradation products. In: Markwardt F (Hrsg) Fibrinolytic and Antifibrinolytics, P. Springer, Berlin Heidelberg New York, p 81 Schmid-Schonbein H (1977) Microrheology of erythrocytes and thrombocytes, blood viscosity and the distribution of blood flow in the microcirculation. In: Meesen H (Hrsg) Handbuch der Allgemeinen Pathologie. Springer, Berlin Heidelberg New York, S 289 Vargaftig BB, Chignard M, Le Couedic JP, Benveniste J (1980) One, two, three or more pathways for platelet aggregation.