Chemical Carcinogenesis and Mutagenesis I by H. C. Pitot (auth.), Colin S. Cooper Ph.D., Philip L. Grover

By H. C. Pitot (auth.), Colin S. Cooper Ph.D., Philip L. Grover D.Sc. (eds.)

I were privileged to witness and perform the nice development of information on chemical carcinogenesis and mutagenesis considering 1939 whilst I entered graduate college in biochemistry on the college of Wisconsin­ Madison. I instantly began to paintings with the carcinogenic aminoazo dyes un­ der the course of Professor CARL BAUMANN. In 1942 I joined a fellow graduate pupil, ELIZABE1H CAVERT, in marriage and we quickly started a joyous half­ nership in study on chemical carcinogenesis on the McArdle Laboratory for melanoma learn within the college of Wisconsin clinical tuition in Madison. This collaboration lasted forty five years. i'm very thankful that this quantity is dedi­ cated to the reminiscence of Elizabeth. the $64000 and sundry themes which are reviewed right here attest to the ongoing development of the fields of chemical motor vehicle­ cinogenesis and mutagenesis, together with their contemporary and fruitful union with viral oncology. i think very positive concerning the program of information in those fields to the eventual answer of various difficulties, together with the detection and estimation of the hazards to people of environmental chemical cancer causing agents and re­ lated factors.

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Carcinogenesis 7:2041-2045 Hendrich S, Glauert HP, Pitot HC (1988) Dietary effects on initiation and promotion of hepatocarcinogenesis in the rat. J Cancer Res Clin OncoI114:149-157 Hennings H, Yuspa SH (1985) Two-stage tumor promotion in mouse skin: an alternative interpretation. JNCI 74:735-740 Hennings H, Michael D, Patterson E (1978) Croton oil enhancement of skin tumor initiation by N-methyl-N-nitro-N-nitrosoguanidine: possible role of DNA replication. Proc Soc Exp BioI Med 158: 1-4 Hennings H, Shores R, Mitchell P, Spangler EF, Yuspa SH (1985) Induction of papillomas with a high probability of conversion to malignancy.

Br J Cancer 1:383-386 Bernheim NJ, Falk H (1983) Cancer and the environment. JAm Coll ToxicoI2:23-54 Bertram JS, Kolonel LN, Meyskens FL Jr (1987) Rationale and strategies for chemoprevention of cancer in humans. Cancer Res 47:3012-3031 Biaglow JE (1981) The effect of ionizing radiation on mammalian cells. J Chern Educ 58:144-156 Boehm TLJ, Grunberger D, Drahovsky D (1983) Aberrant de novo methylation of DNA after treatment of murine cells with N-acetoxy-N-2-acetylaminofluorene. Cancer Res 43:6066-6071 Borek C, Sachs L (1968) The number of cell generations required to fix the transformed state in x-ray-induced transformation.

BOUTWELL 1964; PITOT 1978). However, the effectiveness of initiation depends on its relationship in time to cellular replicative DNA synthesis and cell division (YING et al. 1982; ISIllKAWA et al. 1980; HENNINGS et al. 1978). That the period of DNA synthesis itself is critical for the "fixation" and thus irreversibility of initiation has been demonstrated in other systems both in vivo and in vitro (WARWICK 1971; FREI and RITCHIE 1963; MCCORMICK and BERTRAM 1982; BOREK and SACHS 1968). As yet, single initiated cells cannot be unequivocally identified by known methodologies, although a recent report by MOORE and his associates (1987) suggested that single hepatocytes exhibiting the presence of the marker placental glutathione-S-transferase in liver represent initiated hepatocytes.

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