Chemical Carcinogenesis: Models and Mechanisms by Harry V. Gelboin, Frank J. Gonzalez, Sang S. Park, Junji

By Harry V. Gelboin, Frank J. Gonzalez, Sang S. Park, Junji Sagara, Narayana Battula (auth.), Francesco Feo, Paolo Pani, Amedeo Columbano, Renato Garcea (eds.)

About centuries after the verbal exchange via Sir Percival Pott that the "chimney sweeper illness" was once a melanoma and its advice that energetic compounds of soot have been the causative brokers, and approximately one century after the outline of urinary bladder melanoma in dye employees, a massive variety of ingredients were synthesized and feature most likely come into touch with guy. learn in melanoma prevention is of basic significance, and should obtain non-stop aid from new discoveries on melanoma etiology and pathogenesis. If one accepts the multistage version of chemical carcinogenesis, one has additionally to just accept that many occasions happen among the touch of carcino­ genic compounds and their particular objectives and the advance of a clinically recognizable neoplasm. hence, animal stories turn into necessary to elucidate different steps wherein chemical cancer agents set off neoplasia. The research of those steps and the comparative review of experimental versions is key to an realizing of pathogenesis.

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2 per liter). For inoculation, stock cultures which were stored at -70°C, were used. 6 g Bacto Nutrient Broth and 5 g NaCI per liter) and adjusted nephelometrically to a titer of 1 to 2 X 10 9 bacteria (colony forming units per milliliter. 5% agar, Vogel-Bonner E medium with 2% glucose). After incubation of the plates for 2 to 3 days at 37°C in the dark, the colonies (his+ revertants) were counted. All incubations were performed in duplicate or triplicate. Generally, individual values deviated by less than 10 colonies or by less than 10% from the mean.

Thus after a 33 B(aIP- DNA ADDUCTS ACETONE/ [3H)B(a)P B(a)p / [3H)B(a)P B(a)p / [3H)B(a)P . D. o 5 10 15 20 25 30 35 40 (+IANTI - B(a)PDE- dG ADDUCTS ACETONE/[3H)B(a)P B(alp/ [3H)B(a)P B(a)p/[3H)B(aIP . D. o 1 2 3 4 5 6 pmole/mg DNA Fig. 8. 12 ~gm Actinomycin D per ml (bottom bar) for 5 h. The methods used are described in ref. 19. at 5 h and increased very slowly over the period examined. Thus after a period of time of BaP treatment most of the cell cultures examined would produce a very similar BaP-DNA adduct profile with the major adduct due to reaction of (+)-anti-BaPDE with DNA.

A. Merrick and J. K. Selkirk, Benzo(a)pyrene:DNA adduct formation in normal human mammary epithelial cell cultures and the human mammary carcinoma T47D cell line, Cancer Res. 46:2697 (1986). I. Plakunov, T. A. Smolarek, D. L. Fischer, J. C. Wiley Jr. and W. M. Baird, Separation by ion-pair high-performance liquid chromatography of the glucuronide, sulfate and glutathione conjugates formed from benzo[a]pyrene in cell cultures from rodents, fish and humans, Carcinogenesis 8:59 (1987). W. M. Baird and L.

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