By Gordon Ethelbert Ward Wolstenholme, Maeve O'Connor
Chapter 1 Chairman's establishing comments (pages 1–3): W. T. J. Morgan
Chapter 2 basic Chemistry of the Mucopolysaccharides (pages 4–21): M. Stacey
Chapter three Physicochemical stories on Hyaluronic Acids (pages 22–41): B. S. Blumberg and A. G. Ogston
Chapter four Immunochemical methods to Polysaccharide and Mucopolysaccharide constitution (pages 42–63): Elvina Kabat
Chapter five Biosynthesis of Mucopolysaccharides: The Uridine Nucleotides of crew a Streptococci (pages 64–84): Albert Dorfman and J. Anthony Cifonelli
Chapter 6 Sulphated Galactosamine?Containing Mucopolysaccharides (pages 85–92): Roger W. Jeanloz, Pierre J. Stoffyn and Monique Tremege
Chapter 7 The Presence in Cartilage of a fancy Containing Chondroitin Sulphate mixed with a Non?Collagenous Protein (pages 93–115): S. M. Partridge and H. F. Davis
Chapter eight The impartial Heteropolysaccharides in Connective Tissue (pages 116–189): Z. Disch, A. Danilczenko and G. Zelmenis
Chapter nine N?Containing Saccharides in Human Milk (pages 140–156): Paul Lgyorgy
Chapter 10 The Pharmacological results of Polysaccharides (pages 157–186): Rolf Meier
Chapter eleven Mucopolysaccharides of Gram?Negative micro organism: more recent Chemical and organic elements (pages 187–199): Otto Westphal, Otto Luderitz, Erwin Eichenberger and Erwin Neter
Chapter 12 Mucopolysaccharides linked to Blood workforce Specificity (pages 200–215): W. T. J. Morgan
Chapter thirteen Blood crew lively elements of Plant foundation (pages 216–233): Georg F. Springer
Chapter 14 Mucopolysaccharides of Epithelial Mucus (pages 234–244): Lars Odin
Chapter 15 Glycoproteins of Plasma (pages 245–266): Richard J. Winzler
Chapter sixteen Colloidal houses of Urinary Mucopolysaccharides (pages 268–286): N. F. Maclaga and A. J. Anderso
Chapter 17 The Prosthetic staff of a few Mucoproteins and its dating to Influenza Virus (pages 287–295): Alfred Gottschalk
Chapter 18 Neuraminic Acid (pages 296–313): E. Klenk
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Additional resources for Ciba Foundation Symposium - Chemistry and Biology of Mucopolysaccharides
It seems extraordinary in such a highly charged particle, that if all the carboxylic groups are in the carboxylate form, it should tend to coil up so much; the repulsive forces should be quite strong. 1500 ml. so that the charges on it are quite far DISCUSSION 39 apart ; it is a very loose coil. Secondly, these measurements are made a t . properties do change very strongly an ionic strength of around 0 ~ 2 The a t lower ionic strength but a t 0 . 2 and above, variation of ionic strength hac little effect.
J . d i n . , 9, 314). Our analytical figures agree fairly well with those published by these authors, and all the gargoyle extracts from both biopsied and post-mortem material so far examined appear to be similar to each other, containing about 18, 28 and 21 per cent respectively of hexosamine, uronic acid and hexose. The ratio of glucosamine to galactose (employing an ion exchange column separation) was about 5 : 1 in one extract and about 3 . 5 : 1 in the other. Qualitatively, by two-dimensional separations (chromatography followed by electrophoresis and staining with toluidine blue), several acid polysaccharides appeared to be present in the extracts and a small proportion behaved as chondroitin sulphate.
To interpret a property of the solution in terms of the characteristics of the solute particles requires a theory of how these characteristics are related to the property in question. Such a theory is usually applicable only under defined HYALURONIC ACIDS: PHYSICOCHEMICAL STUDIES 27 conditions, in which the behaviour of the system is particularly simple. The most important of such conditions is that interactions between solute particles shall be absent. Since this holds only a t zero concentration, measurements must be carried to as low a concentration as possible and extrapolated to zero concentration.