By E. C. Lasser (auth.), Prof. Dr. Michel Amiel (eds.)
Journalists, consistently very direct and looking for sensation, primarily requested me questions about the party of this workshop: What have been the ambitions of the assembly? With the advance of prognosis during the improvement of photograph recommendations, did not the distinction media have already got their destiny in the back of them? Many solutions have been supplied through the process the workshop, and so as to top solution the newshounds I proposed the next synopsis. 1. because the 1979 Colorado Springs workshop prepared by way of E. Lasser, development has been so quick and the newly to be had works so a variety of that one other assembly on a global point for the aim of pre senting and discussing those advances seemed fundamental. Why now not then in Europe and why no longer in Lyon? To extend in this development, by way of 1981 the hot distinction media with less-hyperosmolar molecules, nonetheless within the trial level in 1979, have been al so much all on hand commercially for angiography, albeit at prohibitive costs. some great benefits of those numerous media have gotten higher recognized; additionally, within the wake of Lasser's paintings, our knowing of the pathophysiology in their noxious results can also be advancing quickly as a result of using versions (for the objective organs: middle, vessel wall, anxious process, kidney; and for the extra common reactions: blood cells, coagulation, supplement procedure, circulating enzymatic systems). moreover, additional new molecules are at the moment being studied in re seek laboratories. 2.
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Extra resources for Contrast Media in Radiology: Appraisal and Prospects
H. Bor Introduction The analysis of allergic status due to iodinated contrast media is made difficult by the variety of clinical manifestations and pretreatment of all patients suspect of being allergic. Because of our long and quite satisfactory experience of HBDT (Human Basophil Degranulation Test) in drug allergy we chose this technique for our study. Material and Methods We used ioxithalamic and ioxaglic acid as haptens; they become antigenic when bound to a macromolecule. A randomized study of 103 patients coming for intravenous urography (93%), cholecystography (3%), arteriography (2%), cholangiography (1%), and hysterography (1%) was made.
Sodium amidotrizoate (Urografin, Sthering Laboratory) in 12 patients Low doses (60 ml) of CM were injected intravenously in one arm and venous blood samples were obtained by the same route after abundant rinsing of the catheter. with a buffer solution. Three samples of blood were drawn: before, 90 s, and 30 min after the injection. Measurement of Complement Values Whole complement tests (CH 50) were performed with a hemolytic microtiterplate assay. Dilutions of sera were made in gelatin veronal buffer by using micro titer dilutions and U-bottom microtiter plates.
Theoretically, the clinical symptoms of SAR can be deduced from the function of activation products of these systems. From a chemist's point of view, the crucial factors of RCM toxicity are: (1) osmolarity, (2) protein binding, (3) changes of membrane potential by RCM cations. Coagulation and RCM Global Tests Thrombin time, reptilase time, partial thromboplastin time, calcium thromboplastin time, and thrombin coagulase time all show a dose-dependent lengthening of clotting time by RCM, hepatotropic RCM being by far the more effective.