By WHO Technical Report Series
This record of a WHO specialist Committee reports present wisdom of Chagas affliction and its pathogenesis discusses the causative parasite the triatomine vectors and the typical reservoirs of an infection and considers the epidemiology and occurrence developments of the disorder. Prevention and keep watch over thoughts are defined as are a few of the formal projects for interruption of ailment transmission. The file concludes via picking priorities for examine and supplying counsel for the making plans implementation and strengthening of nationwide keep an eye on courses.
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Extra info for Control of Chagas Disease: 2nd Report of the WHO Expert Committee on Chagas Disease (Technical Report Series)
2 The changes associated with domiciliation The domiciliation of triatomines is the main factor in increasing the risk of T. cruzi transmission to humans. g. multilocus enzyme electrophoresis (MLEE), DNA methods, or morphometrics, can help in elucidating the genetic and phenotypic changes associated with domiciliation. These techniques have shown that the process is usually associated with major migrations, the reduction of genetic repertoire, and increasing developmental instability, making the insect a more efficient vector as well as a more vulnerable target of control measures.
The main epidemiological applications of population genetics in triatomines are those concerned with systematics and studies of population structure. Population genetics focuses on genes, DNA fragments, or any trait considered to be a Mendelian factor, and their frequencies in various populations. Relevant techniques include the traditional MLEE and the more recent DNA methods. Analytical methods currently rely on certain probabilistic models defining genetic equilibrium. They delineate the expected features of genetic variability (heterozygosity) as well as of gene frequencies — or the frequency of DNA fragments — within and among populations.
Cruzi II with the domestic cycle, while T. cruzi I was preferentially encountered in the sylvatic environment (52). Since all parasites isolated from seropositive individuals from endemic regions belong to T. cruzi II, it is suggested that this group has properties that favour human infections and promote higher parasitaemia. On the other hand, in Amazonas, T. cruzi I was isolated from wild triatomines but from only a very small number of seropositive people with low parasitaemia and the indeterminate form of Chagas disease (52).