Cytokines as Potential Therapeutic Targets for Inflammatory by B. Skurkovich, S. Skurkovich (auth.), R. Numerof, C. A.

By B. Skurkovich, S. Skurkovich (auth.), R. Numerof, C. A. Dinarello, K. Asadullah (eds.)

Cytokines and cytokine receptors stay a space of serious curiosity for the improvement of unique treatments for cutaneous inflammatory ailments. Anti-TNF therapeutics have confirmed to be potent within the therapy of psoriasis, and medical investigations have now began for different cytokine-directed remedies, comparable to these concentrating on IFN-g, IL-12p40, and IL-18. as well as therapeutics that focus on cytokines without delay, innovations that focus on cytokine signaling pathways are in improvement. This publication summarizes the findings of the 56th overseas Workshop of the Ernst Schering learn beginning that serious about "Cytokines as capability healing objectives for Inflammatory epidermis Diseases".

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IL-15 also induces NK cell activation, measured either by direct cytotoxicity, antibody-dependent cellular cytotoxicity or production of cytokines. It has been directly implicated in promoting NK cell mediated shock in mice. Moreover, IL-15 is implicated in thymic development of T cell and, particularly, NK cell lineages. IL-15 likely also functions as an NK cell survival factor in vivo by maintaining Bcl-2 expression (reviewed by Fehniger and Caligiuri 2001). g. intercellular adhesion molecule [ICAM]-3) redistribution (Wilkinson and Liew 1995; Nieto et al.

1987), rheumatoid arthritis (Seitz et al. 1988), psoriasis (Fierlbeck et al. 1990), and others. IFN-α can also induce underlying autoimmune 16 B. Skurkovich, S. Skurkovich diseases, including autoimmune thyroid disease (Murakami et al. 1999), type I diabetes (Fabris et al. 1998), and rheumatoid arthritis (Pittau et al. 1997). In multiple sclerosis, evidence points to IFN-γ as having a direct role in inducing central nervous system demyelination (Horwitz et al. 1997). IFN-γ in chronic high levels may set in motion the autoimmune process.

Mediators Inflamm 12:309–313 Kageyama Y, Koide Y, Yoshida A et al (1998) Reduced susceptibility to collageninduced arthritis in mice deficient in IFN-gamma receptor. J Immunol 161:1542–1548 Karlsson H, Bachmann S, Schroder J, McArthur J, Torrey EF, Yolken RH (2001) Retroviral RNA identified in the cerebrospinal fluids and brains of individuals with schizophrenia. Proc Natl Acad Sci U S A 98:4634–4639 22 B. Skurkovich, S. Skurkovich Karpuzoglu-Sahin E, Hissong BD, Ansar Ahmed S (2001) Interferon-gamma levels are upregulated by 17-beta-estradiol and diethylstilbestrol.

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